| Akl, Elie | Medicine | | Approximately 1 Year
| In a hospital
|
Mentor:
Elie Akl Department:
Medicine Description:
Systematic review of the medical literature to identify and abstract data from papers reporting systems/methods to assess academic productivity (clinical, research, teaching, administrative) and paper reporting guidelines/systems/methods/criteria and procedures for appointment, promotion, and tenure Duration:
Approximately 1 Year
Location:
In a hospital
|
| Akl, Elie | Medicine | | Approximately 1 Year
| In a hospital
|
Mentor:
Elie Akl Department:
Medicine Description:
Systematic review of the medical literature to identify and abstract data from papers reporting patient preferences for treatment options and values assigned to outcomes in the area of thromboembolic disease Duration:
Approximately 1 Year
Location:
In a hospital
|
| Akl, Elie | Medicine | | Approximately 1 Year
| In a hospital
|
Mentor:
Elie Akl Department:
Medicine Description:
Systematic review of the medical literature to identify and abstract data from papers reporting on the prevalence, behavior, beliefs, and outcomes of using waterpipe (hookah) smoking Duration:
Approximately 1 Year
Location:
In a hospital
|
| Akl, Elie | Medicine | | Approximately 1 Year
| In a hospital
|
Mentor:
Elie Akl Department:
Medicine Description:
Survey study of foreign born physicians practicing in the US about their future intentions to return to their country of origin vs. staying in the US. Duration:
Approximately 1 Year
Location:
In a hospital
|
| Amankwah, Kofi | Gynecology-Obstetrics | Clinical Trial Research
| Longer Than 1 Year
| In a hospital
|
Mentor:
Kofi Amankwah Department:
Gynecology-Obstetrics Description:
Gestational diabetes will be screened at 130. We screen them at 140. However, since 68% of our patients are obese, I suspect we are missing a lot of them. Research Type:
Clinical Trial Research
Duration:
Longer Than 1 Year
Location:
In a hospital
|
| Ambrus, Julian | Medicine | Basic Science Research (laboratory)
| Approximately 1 Year
| In a hospital
|
Mentor:
Julian Ambrus Department:
Medicine Description:
a. Autoimmunity, Sjogren's disease ~ the IL-14a TG mice are an excellent model for Sjogren's disease, reproducing the injury to the salivary glands, manifestations, immunological changes and late onset lymphomas in the same relative time frame as seen in patients with Sjogren's disease. Prelirninary work has demonstrated that salivary gland injury initially involves cytokines and autoantibodies (manuscripts to be submitted soon) rather than lymphocytes. NIH grants are pending to evaluate 1) the genetic changes correlating with the phenotypic changes, the nature of the autoantigens recognized early in the disease, 3) the cytokines contributing to direct salivary gland injury, 4) the B lymphocyte subpopulations necessary for various manifestations of disease, 5) the contribution of T cells to the disease and 6) the ability to inhibit the disease in IL-14aTG mice and other animal models (NOD, MRL/lpr, NZB xNZ\V) by blocking IL-14 with an siRNA, or antibody or in 1L-14 - /- mice. Observations made in these mice will be evaluated in patients with both early and late primary and secondary Sjogren's syndrome.
b. Lymphoma - we have several animal unique animal models for various forms of iyrnphoma: 1) the IL-14o. TO mice for the large B cell lymphomas associated with autoimmune disease (3), 2) the 1L-14o. x C-myc double transgenic (DTO) mice for blastoid-variant mantle cell lymphoma [ the only animal model in the world for this tumor] (8)~ 3) 1L-14(3 mice for follicular lymphoma (manuscript in preparation; the only animal model in the world for this tumor), and 4) the IL-14~ x double transgenic (DTGI3) mice for a yet uncharacterized aggressive large B cell lymphoma. For each of these tumors there are similar questions, which grants have been written some but not all cases: 1) what Chr01110S0nlal changes contribute to the development of the tumors, 2) what changes in n1RNA and miHNA contribute to different stages of tumor development, 3) what B cell subpopulations rise to the tumors, 4) what changes can identify the earliest form of the tumors, 5) what distinguishes the rapidly proliferating tlU110r from its "tumor stern cells", 6) what genese, including IL-14~ are therapeutic targets and how should they be targeted and 7) how closely do these tumors mimic their human counterparts. This work is being done in collaboration with John Cowell PhD, and various other members of the Department of Genetics at Roswell Park Cancer Institute as well as with Richard Ford. MD, PhD and various members of the Department of Pathology at MD Anderson Cancer Center. Research Type:
Basic Science Research (laboratory)
Duration:
Approximately 1 Year
Location:
In a hospital
|
| Arroyo, Armando | Gynecology-Obstetrics | Basic Science Research (laboratory)
| Approximately 1 Year
| In a hospital
|
Mentor:
Armando Arroyo Department:
Gynecology-Obstetrics Description:
Ion channels in GARH neurons.
Immunohistochemistry
Rat brain Research Type:
Basic Science Research (laboratory)
Duration:
Approximately 1 Year
Location:
In a hospital
|
| Awayda, Mouhamed | Physiology and Biophysics | Translational Research (Basic Research Involving Humans)
| Approximately 1 Year
| In a hospital
South Campus
|
Mentor:
Mouhamed Awayda Department:
Physiology and Biophysics Description:
The Project examines proteases that cleave and activate the epithelial sodium channel. We utilize a simple assay that tests biological fluids for channel cleaving proteases as well as examining channel processing by Western Blotting. The effect of various biological variables, such as diet and exercise or intrinsic variable, such as race and sex, on protease levels and overall renal sodium handling will be examined Research Type:
Translational Research (Basic Research Involving Humans)
Duration:
Approximately 1 Year
Location:
In a hospital
South Campus
|
| Berenson, Charles | Medicine / Infectious Diseases | Basic Science Research (laboratory)
Translational Research (Basic Research Involving Humans)
| | At the VA Medical Center
|
Mentor:
Charles Berenson Department:
Medicine / Infectious Diseases Description:
Immunoregulatory roles JacrOPhagC gangliosides.
Role of alveolar macrophages in the pathogenesi s of COPD
Haernophilus influenzae adherence
Research interests of this lab~ratOryfocus on two key areas. Ou first area of interest concentrateson the immunol gic roles of mammalian macroph ge gangliosides, Gangliosides are sialylated glycosphingoli ids that hold diverse irnmunoregu atory roles ~8 receptors and as mediators of ceUular differentiation in many eukaryotic cells. 0 r studies have encompassed ganglioside regulation of macrophage cytokine production, gan lioside-associated membrane architectural alterations in mjv-infectcd macrophages, and the r ceptor roles of macrophage gangliosides for bacterial pathogens. This work will lead to bettlr understanding of mechanisms of macrophage activation, to. rltimatcly permit manipulation of .ost immune cellular responses.
Our second area of interest b9~terf.l on the imrnunomodulation 0 inflammatory responses human alveolar macrophageslby specific antigens of nontypeabl Hacmophilus influenzae, contributing to the pathogene~is of COPD. Studies encompass d fining the repertoire of inflammatory mediators of human alveolar and blood-derived m crophages, modulated by I antigens of Haernophilus influenzae and characterizing Nl'Hl-re ulated functional and phenotypic immunologic properties of macrophages, in patients ith COPDcompared.with normal subjects. These investigations into fundamental mechani IDS of the inflammatory responses of immune cells aIl~ their contribution to CUPD will provide the basis for designing novel and more effective therapies, Research Type:
Basic Science Research (laboratory)
Translational Research (Basic Research Involving Humans)
Location:
At the VA Medical Center
|
| Bett, Glenna | Gynecology-Obstetrics | Basic Science Research (laboratory)
Translational Research (Basic Research Involving Humans)
| 3 Months
6 Months
Approximately 1 Year
Longer Than 1 Year
| In a hospital
South Campus
|
Mentor:
Glenna Bett Department:
Gynecology-Obstetrics Description:
We have several projects available involving translational research into the molecular basis of the initiation of ecitation-contraction coupling that results in labor and parturition in humans and/or animal models. The length and complexity of the project will be determined by the time commitment from the student, and the skills the student wishes to acquire. A minimum of 3 months commitment is required in order to gain sufficient skills to complete the minimum project. Research Type:
Basic Science Research (laboratory)
Translational Research (Basic Research Involving Humans)
Duration:
3 Months
6 Months
Approximately 1 Year
Longer Than 1 Year
Location:
In a hospital
South Campus
|
| Bradford, Peter | Pharmacology | Basic Science Research (laboratory)
| 3 Months
| South Campus
|
Mentor:
Peter Bradford Department:
Pharmacology Description:
Apoptosis, or programmed cell death} is a physiological cell suicide response essential for normal homeostasis. Deregulated apoptosis is associated with proliferative diseases such as cancers and with
degenerative diseases like osteoporosis. In osteoblasts, estrogen deficiency is associated with osteoporosis and accelerated apoptosis. Preliminary studies have shown that added estradiol inhibits apoptosis as well as caspase-3 activation in G-292 osteosarcoma cells} a model cell line for osteoblasts. Proposed research studies will follow-up these investigations using cultured primary human osteoblasts. Primary osteoblasts derived from bone fragments extracted through dental surgeries will be cultured and treated with or without estradiol prior to incubation with apoptosis-promoting agents such as TNF. Measurements of specific apoptosis-regulatory factors will be made at the levels of mRNA} protein} and activity. Focus is directedtowardsthe specific effects on pro-apoptotic regulatory factor} BID} and the inositol trisphosphate receptor. Assays will include real-time PCR and immunoblot analyses. Research Type:
Basic Science Research (laboratory)
Duration:
3 Months
Location:
South Campus
|
| Cadzow, Renee | Family Medicine | Translational Research (Basic Research Involving Humans)
| 3 Months
| At a private practice site
|
Mentor:
Renee Cadzow Department:
Family Medicine Description:
The Lockport NY public school district and the University at Buffalo Primary Care Research Institute are conducting a community wide assessment of child and adolescent obesity. Funded by a U.S. Department of Education Physical Education Program (PEP) grant, the project addresses a great need in the community and may serve as a model for other community obesity and fitness assessments. The project aims to assess obesity and physical fitness among children in the community and evaluate school and community based methods to improve theirhealth, It is a longitudinal (3 year) cohort study in a small city and surrounding town in Western New York State. Over 4000 children in grades 3-12 have height and weight measured biannually. Body Mass Index (BM!) percentile is figured from these measurements. Additionally, students participate in the PACER (Progressive Aerobic Cardiovascular Endurance Run) aerobic capacity test, core strength test (sitting knee raise), and upper body strength test (perfect push-up) biannually as well as quarterly physical activity questionnaire (PAQ-C and PAQ-A). Preliminary results indicate that the overweight rate exceeds the national rate of 150/0; 17% of students (21% of elementary, 18% of middle, and 15°,/0 of high school students) are classified as overweight (> 95th percentile BMI for age and sex). 44% of middle and 62°,/0 of high school students have a below healthy aerobic fitness status. Even among those with a healthy weight, more than half of high school and one third of middle school students have low aerobic fitness. Around 90% of those that are overweight have low aerobic fitness status. 30% of middle and high school students had a low or moderately low level of physical activity frequency. Medical student researchers may participate in literature review, data analysis and interpretation, and manuscript development. Application of the data to child and adolescent primary care provider recommendations is strongly encouraged. A similar body of data exists for Niagara Falls, NY that may be combined/compared with the Lockport data. Also, complementary chart review of child and adolescent patients of an urban Buffalo, NY practice site will be possible. Research Type:
Translational Research (Basic Research Involving Humans)
Duration:
3 Months
Location:
At a private practice site
|